Electric Literature of 150058-27-8, These common heterocyclic compound, 150058-27-8, name is Methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 4. Under nitrogen atmosphere, bromide (1.0 mmol, 1.0 equiv.), methyl 2-ethoxy-1Hbenzo[d]imidazole-7-carboxylate (1.02 mmol, 1.02 equiv.), potassium carbonate (2.1 mmol, 2.1 equiv.)and a stirring bar were added into a 15 mL sealed glass tube. Then the Schlenk was sealed and DMF(6 mL) was injected by a syringe. The reaction was stired for 24 hr at room temperature. After thereaction was finished, the mixture was diluted with DCM (20 mL) and washed with water, and then thesolvent was removed under vacuum. The residue was purified with flash chromatography on silica gel(gradient eluent of petroleum ether/ ethyl acetate: 5:1) to give the methyl 1-((2′-(cyano-13C-15N)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate in 64% yield.
The synthetic route of 150058-27-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Hua; Dong, Yanan; Zheng, Chaonan; Sandoval, Christian A.; Wang, Xue; Makha, Mohamed; Li, Yuehui; Chem; vol. 4; 12; (2018); p. 2883 – 2893;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem