Related Products of 693-98-1, These common heterocyclic compound, 693-98-1, name is 2-Methyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Methylimidazole (21) (925 mg, 11.27 mmol) was dissolved in THF (40 mL), cooled to 0 C and sodium hydride 60% in mineral oil (500 mg, 12.50 mmol) was added portion wise over 5 min. After 30 min of stirring at 0 C, 2-(trimethylsilyl)ethoxymethyl chloride (2.00 mL, 11.30 mmol) was added dropwise and the mixture was stirred at rt for 18 h. Purification by flash chromatography (SiO2, n-hexane/EtOAc 90:10 to 60:40) afforded 22 as a clear oil (2.30 g, 96%). 1H NMR (300 MHz, CDCl3) delta 0.02 (s, 9H),0.82e0.95 (m, 2H), 2.43 (s, 3H), 3.39-3.53 (m, 2H), 5.18 (s, 2H), 6.90(s, 2H).
The synthetic route of 693-98-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Heider, Fabian; Ansideri, Francesco; Tesch, Roberta; Pantsar, Tatu; Haun, Urs; Doering, Eva; Kudolo, Mark; Poso, Antti; Albrecht, Wolfgang; Laufer, Stefan A.; Koch, Pierre; European Journal of Medicinal Chemistry; vol. 175; (2019); p. 309 – 329;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem