Application of 96797-15-8,Some common heterocyclic compound, 96797-15-8, name is 4-Iodo-1-trityl-1H-imidazole, molecular formula is C22H17IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 4-iodo-l-tritylimidazole (commercially available, 5.1 g, 1 1.8 mmol) in dichloromethane (40 ?iL) at -10 0C was treated with ethyl magnesium bromide (3.9 mL, 1 1.8 mmol, 3M in ether) and allowed to react for 45 m. A solution of 3-chloro-2-fluoro-benzaldehyde, (Intermediate 1) (1.5 g, 9.4 mmol) in dichloromethane was added via syringe at -10 0C and stirred for 16 hours at room temperature. The mixture was quenched with water (50 mL) and a saturated solution of ammonium chloride (50 mL). The residue was isolated in a typical aqueous workup and purified by MPLC with 3 to 5 % MeOHiCH2Cl2 to give (3-chloro-2-fluorophenyl)(l-trityl-l H-imidazol-4-yl) methanol, (Intermediate 2) as a solid, (3.5 g 78
The synthetic route of 96797-15-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALLERGAN, INC.; WO2008/141312; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem