Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10111-08-7, name is Imidazole-2-carboxaldehyde, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives
Preparation of 4-[(2′-dimethylaminomethyl)imidazol-1′-yl]aniline. To a solution of 4-fluoronitrobenzene (7.87 g) and 2-imidazole-carboxaldehyde (5.90 g) in DMF (60 mL) was added K2CO3 (9.26 g). The mixture was heated at 80C under N2 for 16 h. The mixture was poured into water, and the precipitate was filtered to give 6.70 g of yellow solid. The filtrate was then extracted with EtOAc, and the organic layer was washed brine, dried over MgSO4, and concentrated to a yellow solid (5.40 g). Both batch were identified as the 4-[(2′-carboxaldehyde)imidazol-1′-yl]nitrobenzene. ESI mass spectrum z (rel. intensity) 218 (M+H, 100).
The synthetic route of 10111-08-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bristol-Myers Squibb Pharma Company; EP991638; (2005); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem