Reference of 3034-50-2, These common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: preparation of tert-butyl 4-formyl-1 H-imidazole-1-carboxylateTo di-tert-butyl dicarbonate (23.25 g, 107 mmol) and 1H-imidazole-4-carbaldehyde (9.75 g,101 mmol) in THF (200mL) was added DMAP (100 mg, 0.819 mmol). The reaction was stirredfor two hours. The reaction mixture was then diluted with saturated NaHCO3 solutuion/EtOAc(100 mL/100 mL). The aqueous was then extracted with EtOAc (2 x 100 mL) and thecombined organic was dried (Na2504) and concentrated to give crude product (19.9 g). m/z197.2 (M + H)
Statistics shows that Imidazole-4-carbaldehyde is playing an increasingly important role. we look forward to future research findings about 3034-50-2.
Reference:
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; LIU, Gang; SHULTZ, Michael David; VAN DER PLAS, Simon Cornelis; WO2014/141153; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem