Electric Literature of 72-40-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72-40-2 name is 5-Amino-1H-imidazole-4-carboxamide hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred suspension of 5-amino-I H-imidazole-4-carboxamide hydrochloride (1 Og, 0.061 5 mol) in acetonitrile (80 mL) was added diisopropylethylamine [DIPEA (12g. 0.0958 mol)] at room temperature. The reaction mixture was stirred at room temperature for 1 0mm followed by 4-nitrophenyl methylcarbamate (25g, 0.1270 mol) was added. The reaction mixture was stirred at room temperature for 24h. After consumption of starting material, the reaction mixture was filtered and the cake washed with acetonitrile (20 mL). The obtained solid was slurried in acetonitrile (80 mL), filtered and cake washed with acetonitrile (20 mE). The obtained solid dried at room temperature for 24h to afford 5-amino-NI-methyl-i H-imidazole1, 4-dicarboxamide (10 g) as an off white solid.?HNMR (DMSO-d6): 8.41 (q, 1H), 7.59 (s, 1H), 6.86 (bs, IH), 6.77 (bs, 1H), 6.35 (s, 2H), 2.78 (d, J 3.2 Hz. 3H);Mass (ni/z): 183.9 (M+); HPLC purity: 98.13%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Amino-1H-imidazole-4-carboxamide hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; GRANULES INDIA LIMITED; VETUKURI, Prasada Raju VNKV; RAPOLU, Rajesh Kumar; NARAYANA, Rama Krishna Reddy; CHIGURUPATI, Krishna Prasad; CHATURVEDI, Akshay Kant; (20 pag.)WO2018/122724; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem