Application of 1231930-33-8,Some common heterocyclic compound, 1231930-33-8, name is 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole, molecular formula is C11H12BrFN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo [d] imidazole (9.0 g, 33.2 mmol)Bis-boronic acid pinacol ester(0.65 g, 49.8 mmo1), palladium acetate (840 mg), tricyclohexylphosphine (1.63 g) and potassium acetate (9,78 g, 99.8 mmo 1) were added to 60 mL of DMSO and the nitrogen was allowed to warm to 80 C for 6 h.The organic phase was extracted with EA, and the organic phase was washed with EA. The organic phase was dried with anhydrous sodium sulfate and filtered through the filtrate. The filtrate was concentrated and purified by silica gel column chromatography (PE: EpsilonAlpha = 1: 2) The title compound (6.0 g, yield 56.8%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole, its application will become more common.
Reference:
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wu, Yongqian; (45 pag.)CN104910137; (2017); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem