Reference of 2849-93-6, These common heterocyclic compound, 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
0.064 mmol of BENZIMIDAZOLECARBOXYLIC acid 41 was dissolved in DMF together with 0.064 MMOL of the amine 5d, a solution of TBTU (0.096 MMOL) in DMF, HOBT (0.026 MMOL) in DMF and 0.32 MMOL of DIPEA were added successively, and the mixture was stirred at room temperature. After 2.5 hours, 0.2 eq. of acid was added, and the mixture was stirred overnight. After further addition of 0.2 eq. of acid, the reaction mixture was diluted with water after 3 hours, and the resulting precipitate was filtered off with suction, washed with water and digested with diethyl ether. Yield : 76%, pale-beige solid
The synthetic route of 2849-93-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GmbH; WO2005/4863; (2005); A1;,
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