16042-25-4, name is 2-Imidazolecarboxylic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-Imidazolecarboxylic acid
A mixture of 1 H-imidazole-2-carboxylic acid (15 mg, 0.13 mmol), aniline lnt-9a (54 mg, 0.13 mmol), diisopropylethyiamine (46 muIota_, 0.27 mmoi) and HATU (56 mg, 0.15 mmol) was stirred in N,N-dimethylformamide (3 mL) at r.t. overnight. Water and ethyl acetate were added, and the layers were separated. The separated organic layer was washed with water. The separated organic layer was dried (MgS04) and filtered. The solvents were removed in vacuo and chromatographic purification (ethyl acetate – hexane) of the residue gave amide lnt-9b (21 mg, 32%) as a white solid.
The synthetic route of 16042-25-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; TSUI, Hon-Chung; PALIWAL, Sunil; KIM, Hyunjin, M.; KEREKES, Angela, D.; CAPLEN, Mary Ann; ESPOSITE, Sara, J.; MCKITTRICK, Brian, A.; FISCHMANN, Thierry Olivier; DOLL, Ronald, J.; RAINKA, Matthew Paul; LI, Ang; WO2011/149874; (2011); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem