Related Products of 6478-73-5, These common heterocyclic compound, 6478-73-5, name is 5,6-Dichloro-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 23[0164] Preparation of (4aR, 7R, 8S,8aR) 5, 6-dichloro-1- (8-fluoro-2-phenyl-hexahydro- pyrano [3,2-d] [1,3]dioxin-7-yl)-1 H-benzoimidazole. EMI54.1[0165] To a solution of (4aR, 7S, 8R, 8aR) trifluoromethanesulfonic acid 8-fluoro-2- phenyl-hexahydropyrano [3,2-d] [1, 3] dioxin-7-yl ester (47.2 mg, 0.12 mmol), prepared according to earlier procedures, in 5 mL of DMSO was added 5, 6-dichloro-1H- benzoimidazole (524 mg, 2.8 mmol) and NaH (67 mg, 2.8 mmol). The mixture was stirred at 70 C overnight. After aqueous work-up and extraction with Et2O, The combined organic fractions were washed with brine, dried over Na2S04, filtered, and concentrated in vacuo. The crude product was purified by flash chromatography to give (4aR, 7R, 8S, 8aR) 5, 6-dichloro-1- (8-fluoro-2-phenyl-hexahydro-pyrano [3,2-d] [1,3] dioxin- 7-yl)-1 H-benzoimidazole. [0166] Yield: 29. 4 mg (58%); Rf= 0. 5 (1: 1 EtOAc-hexane). 1H NMR (CDCl3, 300 MHz) 6 3.61-3. 75 (1H, ddd), 3.80 (1H, dt), 4.14 (1H, m), 4.44-4. 51 (3H, m), 4.66 (1H, m), 5.05-5. 21 (1H, d), 5.49 (1H, s), 7.26-7. 44 (5H, m), 7.60 (1H, s), 7.97 (1H, s), 8.51 (1H, s).
Statistics shows that 5,6-Dichloro-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 6478-73-5.
Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; WO2005/49582; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem