Related Products of 51-17-2, A common heterocyclic compound, 51-17-2, name is 1H-Benzo[d]imidazole, molecular formula is C7H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) Put 30 g of water into the reaction kettle, turn on the stirring, and sequentially add 0.06 g of Fe (NO3) 3.9H2O, 15 g of 96% sulfuric acid, 0.03 g of tetrabutylamine bromide, 2.5 g of benzimidazole, and raise the temperature;(2) When the reaction temperature reaches 80 C, 20 g of oxone is added in batches, and the reaction is incubated for 8 hours after the addition.(3) After the reaction is completed, the temperature is lowered to -10 to 10 C, and concentrated ammonia is slowly added dropwise under stirring to adjust the pH value to 0.6 to 1, and then stirring is continued for 1 hour for crystallization, suction filtration, and drying to obtain 4,5-imidazole di Carboxylic acid, the filtrate can be used for further product recovery, yield 73%.
The synthetic route of 51-17-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Changshu Institute of Technology; Yang Yang; Fu Renzhong; Wang Xin; Fang Zhengjiao; Lu Zhengyi; Zeng Xiaojun; (11 pag.)CN110818628; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem