In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 137049-00-4
The product from Example 225C (0.044 g, 0.15 mmol), 1- methyl-1H-imidazole-4-sulfonyl chloride (0.033 g, 0.180 mmol) and triethylamine (0.042 mL, 0.30 mmol) were combined in dichloromethane (0.75 mL), heated at 60 C for 2 hours and concentrated. Purification by chromatography (silica gel, 0-3% methanol in dichloromethane) afforded the title compound (0.038 g, 56%). 1H NMR (300 MHz, DMSO-d6) delta 10.21 (s, 1 H) 7.84 (d, J=1.36 Hz, 1 H) 7.75 – 7.78 (m, 2 H) 7.48 (dd, J=9.49, 2.71 Hz, 1 H) 7.25 – 7.35 (m, 2 H) 7.21 (d, J=2.71 Hz, 1 H) 7.09 (dd, J=8.82, 2.71 Hz, 1 H) 7.03 (t, J=7.46 Hz, 1 H) 6.89 (d, J=8.82 Hz, 1 H) 6.83 (d, J=7.80 Hz, 2 H) 6.37 (d, J=9.49 Hz, 1 H) 3.67 (s, 3 H) 3.43 (s, 3 H). MS (ESI+) m/z 437 (M+H)+.
The synthetic route of 137049-00-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI)COMPANY, LTD.; HUBBARD, Robert Dale; MCDANIEL, Keith F.; PARK, Chang Hoon; PRATT, John K.; SOLTWEDEL, Todd; SUN, Chaohong; WANG, Le; WENDT, Michael D; WO2013/185284; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem