Adding a certain compound to certain chemical reactions, such as: 1467-16-9, name is 1H-Imidazole hydrochloride, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1467-16-9, Product Details of 1467-16-9
A mixture of lithium(1+) ion 3-amino-7-bromo-5/-/-pyrrolo[2,3- 5]pyrazine-2-carboxylate, Intermediate 163 (243 mg, 0.924 mmol), CDI (300 mg, 1.85 mmol) and imidazole hydrochloride (116 mg, 1.11 mmol) in DMF (3 ml) was stirred at RT for 1 h 15 min. Additional CDI (100 mg, 0.617 mmol) was added then the reaction was left to stir at RT for a further 1 h. The reaction mixture was diluted with water (5 ml) then stirred at RT for 10 min. The resultant suspension was filtered then the collected solid was washed with water (2 x 5 ml), then dried in vacuo to afford the product as a yellow solid (218 mg, 77%). 1 H NMR (500 MHz, DMSO-cfe) delta 12.05 (s, 1 H), 8.89 – 8.82 (m, 1 H), 8.03 – 7.99 (m, 1 H), 7.86 (s, 1 H), 7.58 (s, 2H), 7.13 – 7.09 (m, 1 H). LC/MS (System A): m/z (ESI+) = 307 [M(79Br)H+], 309 [M(81 Br)H+], Rt = 0.81 min, ELS purity = 100%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; MCCARTHY, Clive; HARGRAVE, Jonathan, David; HAY, Duncan, Alexander; SCHOFIELD, Thomas, Beauregard; WENT, Naomi; (261 pag.)WO2018/96325; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem