Adding a certain compound to certain chemical reactions, such as: 14700-62-0, name is 2-Benzyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14700-62-0, Recommanded Product: 2-Benzyl-1H-imidazole
a) N,N-dimethylformamide (200 ml) was stirred at room temperature under nitrogen and a dispersion sodium hydride 50% in mineral oil (0.113 mol) was added portionwise. 2-Phenylmethyl-1H-imidazole (0.075 mol) was added portionwise and the mixture was stirred for 1 hour at room temperature. Ethyl chloroacetate (0.113 mol) dissolved in N,N-dimethylformamide was added dropwise and the mixture was stirred at room temperature for 30 minutes. The mixture was poured into a NaHCO3 solution and extracted with dichloromethane. The organic layer was dried (MgSO4), filtered off and evaporated. The residue was purified on a glass filter over silica gel (eluent: CH2 Cl2 /CH3 OH 95/5). The pure fractions were collected and evaporated, yielding 16 g (93%) of product. A sample (1 g) was crystallized from 2,2′-oxybispropane/acetonitrile, yielding 0.58 g of methyl 2-(phenylmethyl)-1H-imidazole-1-acetate; mp. 70.8 C. (interm. 21). A mixture of intermediate (21) (0.017 mol) in trifluoromethanesulfonic acid (25 ml) was stirred at 140 C. overnight. The mixture was cooled, poured into a K2 CO3 solution/ice water and extracted with dichloromethane/ethanol.
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Reference:
Patent; Janssen Pharmaceutica N.V.; US5674866; (1997); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem