Adding a certain compound to certain chemical reactions, such as: 16681-56-4, name is 2-Bromo-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-56-4, Formula: C3H3BrN2
Intermediate 124 (150 mg, 0.25 mmol), 2-bromoimidazole (46 mg, 0.31 mmol) andsodium carbonate (79 mg, 0.75 mmol) were suspended in 1 ,4-dioxane (3 mL) andwater (0.25 mL). The reaction mixture was degassed with argon (5 minutes), Pd(PPh3)4 (29 mg, 0.025 mmol) was added and the reaction mixture was heated at 110 C for 12 h in a microwave reactor. The cooled reaction mixture was filtered through celite, washed with EtOAc, then DCM and the filtrate was evaporated in vacuo. The crudematerial was dissolved in THF (4 mL) and TBAF (1M in THF) (1 mL) and heated to40 C for 2 hours. The reaction mixture was concentrated in vacuo and purified bypreparative chromatography using acidic eluent. The material was retrieved andpurified by preparative chromatography using basic eluent to give 6.2 mg of compound163 (6% yield, pale yellow amorphous solid).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1H-imidazole, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; MACLEOD, Calum; MANN, Samuel, Edward; KULAGOWSKI, Janusz, Jozef; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; PONCELET, Virginie, Sophie; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; (290 pag.)WO2019/8011; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem