Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20485-43-2, name is 1-Methyl-1H-imidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below., Formula: C5H6N2O2
Example 14[[3-(2′,4′-Difluoro-biphenyl-4-yloxymethyl)-benzyl]-(1-methyl-imidazole-2-carbonyl)-amino]-acetic acid; [3-(2′,4′-Difluoro-biphenyl-4-yloxymethyl)-benzylamino]-acetic acid ethyl ester (205 mg, 0.5 mmol) was mixed with N-methyl-imidazole-2-carboxylic acid (126 mg, 1.0 mmol) in DMF (6 mL). The mixture was stirred and BOP reagent (331.8 mg, 0.749 mmol), diisopropylethylamine (0.18 mL, 0.97 mmol) was added. The mixture was stirred at room temperature overnight and solvent was evaporated. The residue was extracted with ethyl acetate and saturated ammonium chloride solution. The organic layer was washed with water and concentrated sodium bicarbonate solution. Solvent was removed and the residue was purified through a flash column chromatography (ethyl acetate in hexanes 10% to 100%) to give [[3-(2′,4′-difluoro-biphenyl-4-yloxymethyl)-benzyl]-(1-methyl-imidazole-2-carbonyl)-amino]-acetic acid ethyl ester (237 mg, 91.5% yield).
The synthetic route of 20485-43-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bolin, David Robert; Hayden, Stuart; Qian, Yimin; Thakkar, Kshitij Chhabilbhai; US2011/136792; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem