Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 71759-87-0, name is 4-Iodo-1-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Computed Properties of C4H5IN2
To a solution of 2-benzyloxy-5-(4,4, 5,5-tetramethyl-[i , 3,2]dioxaborolan-2-yl)benzamide (Preparation 162, 5 g, i4.i6 mmol) and 4-iodo-i-methyl-iH-imidazole (2.94 g, i4.i6 mmol) in DMF (60 mL) was added a solution of potassium carbonate (4.89 g, 35.4i mmol) in water (iO mL). The solution was degassed with argon for i5 minutes followed by the addition of iibis(diphenylphosphino)ferrocene palladium (II) dichloride (578 mg, 0.7i mmol). The reactionwas heated to iioC for i6 hours before cooling and diluting with EtOAc (300 mL). The organic solution was washed with water (2 x iOO mL), brine (75 mL), dried over sodium sulphate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 0-4% MeOH in DCM to afford the title compound (i g, 23%).1H NMR (400 MHz, DMSO-d6): O ppm 3.66 (5, 3H), 5.25 (5, 2H), 7.20 (d, iH), 7.34 (t, iH), 7.4i(t, 2H), 7.50-7.54 (m, 4H), 7.59-7.6i (m, 2H), 7.77 (dd, iH), 8.i5 (d, iH). MS mlz 308 [M+H]
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PFIZER LIMITED; SKERRATT, Sarah Elizabeth; BAGAL, Sharanjeet Kaur; SWAIN, Nigel Alan; OMOTO, Kiyoyuki; ANDREWS, Mark David; WO2015/92610; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem