Synthetic Route of 939-70-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 939-70-8 as follows.
General procedure: A solution of 2-acetyl-benzimidazole 4(3.2 g, 20 mmol) and the diversely substituted aromatic aldehydes5a-h (24 mmol) in 40 ml of absolute methanol were taken in a flask.Potassium hydroxide (8.0 g, 142.6 mmol) was added and the reactionmixture was stirred for 24 h at room temperature under TLCmonitoring. The mixture was then poured into crushed ice water.The product obtained is filtered and washed with distilled waterand finally recrystallized from methanol.
According to the analysis of related databases, 939-70-8, the application of this compound in the production field has become more and more popular.
Reference:
Article; Djemoui, Amar; Naouri, Abdelkader; Ouahrani, Mohammed Ridha; Djemoui, Djamila; Lahcene, Souli; Lahrech, Mokhtar Boualem; Boukenna, Leila; Albuquerque, Helio M.T.; Saher, Liza; Rocha, Djenisa H.A.; Monteiro, Fatima Liliana; Helguero, Luisa A.; Bachari, Khaldoun; Talhi, Oualid; Silva, Artur M.S.; Journal of Molecular Structure; vol. 1204; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem