These common heterocyclic compound, 583-42-6, name is 5-Fluoro-1H-benzo[d]imidazole-2(3H)-thione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H5FN2S
Step 2) Synthesis of 2-chloro-5-fluoro-1H-benzo [d] imidazole To a 50 mL of reaction flask were added 5-fluoro-1H-benzo [d] imidazole-2-thiol (1.00 g, 6.57 mmol) and phosphorus oxychloride (25 mL) . The mixture was refluxed for 13 h. After the reaction is complete, the mixture was concentrated to remove excess phosphorus oxychloride. The resulting mixture was quenched with saturated sodium bicarbonate solution (15 mL) , and extracted with ethyl acetate (10 mL ? 3) . The combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as a pale yellow solid (1.03 g, 92.0%) .MS (ESI, pos. ion) m/z: 171.05 [M+H] +.
The synthetic route of 5-Fluoro-1H-benzo[d]imidazole-2(3H)-thione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; JIN, Chuanfei; ZHANG, Ji; (90 pag.)WO2017/88759; (2017); A1;,
Imidazole – Wikipedia,
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