Reference of 28890-99-5, These common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1 a) 20 g (96.5 mmol) 6H-benzimidazolo[1 ,2-a]benzimidazole is dissolved in 400 ml trifluoro- acetic acid under nitrogen. 43.4 g (193 mmol) N-lodosuccinimide is added in 10 minutes. The reaction mixture is stirred at 25 C for 24 h under nitrogen. The precipitated product is filtered off and crystalized from trifluoroacetic acid (yield: 19.2 g (43 %)). 1 H NMR (400 MHz, TFA-d1): delta 8.77-8-78 (m, 2H), 8.34-8.37 (m, 2H), 7.91-7.94 (m, 1 H).
The synthetic route of 28890-99-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IDEMITSU KOSAN CO., LTD (IKC); SCHAeFER, Thomas; RAIMANN, Thomas; NAGASHIMA, Hideaki; (108 pag.)WO2016/16791; (2016); A1;,
Imidazole – Wikipedia,
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