Electric Literature of 6160-65-2,Some common heterocyclic compound, 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, molecular formula is C7H6N4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirring solution of 1,1?-thiocarbonyldiimidazole (1.2 equiv) in5 mL of DMF at 50 C was added a solution of TEA (1 equiv) and amine5 (1 equiv) in DMF dropwise. The resulting solution stirred at roomtemperature for 1-24 h and was monitored by TLC. The resulting crudesolution of the isothiocyanate was used in the next step without purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1′-Thiocarbonyldiimidazole, its application will become more common.
Reference:
Article; Chapa, Jorge De La; Valdez, Matthew; Ruiz, Franscisco; Gonzales, Keith; Mitchell, Wes; McHardy, Stanton F.; Hart, Matthew; Polusani, Srikanth R.; Gonzales, Cara B.; Bioorganic and Medicinal Chemistry; vol. 27; 1; (2019); p. 208 – 215;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem