Synthetic Route of 144690-33-5, The chemical industry reduces the impact on the environment during synthesis 144690-33-5, name is Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, I believe this compound will play a more active role in future production and life.
To a 10 L reaction flask was added 257 gPhenyl) methylimidazol-1-yl) phenyl] propan-1- {4- [2- (triphenylmethyl- Carboxylic acid ethyl ester (Compound II) and 2.8 L 1,4-dioxane were added and dissolved by mechanical stirring,Heating to 45 C, adding 28.6g of sodium hydroxide solution, the reaction 4.5h. To the reaction mixture, 1.5 L of ethyl acetate was added,Stirring, standing layered, separate the organic phase. The aqueous phase was extracted with 1 L of ethyl acetate. The organic phases were combined and the organic phase was chlorinated with 4.5 LSodium aqueous solution. The organic phase was cooled in an ice bath and adjusted to pH 3 to 5 with 20% aqueous acetic acid. The filter cake was washed with 5 L of ethyl acetateEster. The filter cake was dried in a dry oven to constant weight to give 198.6 g of product as a white solid. The yield was 80.4% by weight.The product was 98.5% by HPLC.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Bengbu Tu Shan Fengyuan Pharmaceutical Co., Ltd.; Ma, Qisheng; Li, Baoqin; Sun, Peng; (18 pag.)CN105418593; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem