Related Products of 35445-32-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35445-32-0 name is Ethyl 1,4-dimethyl-1H-imidazole-5-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Add NaOH (0.451 g, 10.7 mmol) to a solution of ethyl 3,5-dimethylimidazole-4- carboxylate (1.00 g, 5.35 mmol) in EtOH (5 mL) and water (5 mL). Stir the reaction mixture at 60 ¡ãC for 1 hr. Concentrate the solution to give the title compound (0.960 g, 99.6percent) as a yellow solid. LC/MS (mlz): 141 (M-21).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1,4-dimethyl-1H-imidazole-5-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; ELI LILLY AND COMPANY; LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD.; HU, Zhilong; LIU, Lianzhu; MA, Tianwei; ZENG, Mi; ZHANG, Haizhen; (37 pag.)WO2018/14800; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem