Reference of 24155-42-8,Some common heterocyclic compound, 24155-42-8, name is 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol, molecular formula is C11H10Cl2N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 1: R- (-) -1- (2,4-dichlorophenyl) -2- (lH-imidazol-1- yl) -ethanol (VI); To a solution of 5 g of 1- (2, 4-dichlorophenyl) -2- (IH- imidazol-1-yl) -ethanol (II) in a mixture of acetone- methanol, 3.21 g of D-tartaric acid dissolved in a mixture of acetone-methanol were added at room temperature. Once the addition was completed, the mixture was stirred for further 30 minutes at room temperature. The resultant solid was filtered and crystallized from methanol. A mixture consisting of the resulting salt, water and methylene chloride was treated with a concentrated solution of sodium hydroxide. The organic layer was washed with water and concentrated at reduced pressure to yield 1.85 g (37%) of (VI) whose enantiomeric purity was higher than 98% in R- {-) isomer.
The synthetic route of 24155-42-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FERRER INTERNACIONAL, S.A.; WO2006/29811; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem