Some common heterocyclic compound, 15965-31-8, name is 5-Chloro-1H-imidazole, molecular formula is C3H3ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Chloro-1H-imidazole
2.2. Synthesis of 1-[(4-chloro-lH-imidazol-1-yl) methyl]-4-(3, 4, 5-trifluorophenyl)- pyrrolidin-2-one 72 using thionyl chloride. Alternatively to method 2.1, 1-imidazol-1-ylmethyl-pyrrolidin-2-ones derivatives can also be obtained by a similar reaction of the hydroxymethyl derivative with successively thionyl choride in toluene for 16 h at room temperature followed by quenching of the chloromethyl derivative with an imidazole in the presence of Et3N at room temperature. For example, 1-hydroxymethyl-4- (3, 4,5-trifluoro-phenyl)- pyrrolidin-2-one reacts with thionyl chloride and 4-chloroimidazole to afford 1- [ (4- chloro-lH-imidazol-1-yl) methyl]-4- (3, 4,5-trifluorophenyl)-pyrrolidin-2-one 72 LC/MS (MH+): 330/332.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15965-31-8, its application will become more common.
Reference:
Patent; UCB, S.A.; WO2005/54188; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem