Related Products of 37067-95-1, A common heterocyclic compound, 37067-95-1, name is 2-Iodo-1-methyl-1H-imidazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
b) Synthesis of N1-methyl-N1-(1-methyl-1H-imidazol-2-yl)ethane-1,2-diamine A mixture of 4.8 g (23.0 mmol) 2-iodine-1-methyl-imidazol, 12.2 ml (138.0 mmol) N-methyl-ethylene-diamine, 80 mg (1.3 mmol) copper and 374 mg (3.8 mmol) copper(I) chloride was heated for 1 h to 70 C. erhitzt. After cooling to RT, the solution was received with brine and DCM and the phases were separated. The organic phase was dried over MgSO4, filtered and concentrated in a vacuum. CC (DCE/EtOH/conc. aq. NH4OH sol. 5:1:0.06) was performed with the residue, whereby 215 mg (1.4 mmol, 6%) N1-methyl-N1-(1-methyl-1H-imidazol-2-yl)ethane-1,2-diamine was obtained.
The synthetic route of 37067-95-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Grunenthal GmbH; US2008/261996; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem