Reference of 7757-21-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7757-21-3 name is (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2,4-Dichloro-benzylamine (47.3mg 0.269mmol) and 3,4-diraethoxy-3- cyiclobutene-l,2-dione (38.2mg, 0.269mmol) were combined in MeOH (2 ml) and water 104 (2ml) and stirred for 2h. C-(lH-benzoimidazol-2-yl)-methylamine HCI (59.4 mg, 0.269mmol) and sat. aHC( (lml) was added in situ. The mixture was stirred at room temperature overnight. After the mixture was extracted with ethyl acetate, washed with brine, concentrated under vacuum and purified via flash column chromatography to yield 3- [(lH-Benzoiniidazol-2-ylmemyl)-amino]-4-(2,4-dicUoro-benzylam dione(1769). LC/MS: (ESI) (M l i s 402.5.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-Benzo[d]imidazol-2-yl)methanamine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITY OF WASHINGTON; BUCKNER, Frederick, S.; ALVAREZ, Ximena, Barros; FAN, Erkang; GILLESPIE, John, Robert; HOL, Wilhelmus, G.J.; HUANG, Wenlin; KOH, Cho, Yeow; RANADE, Ranae, M.; SHIBATA, Sayaka; VERLINDE, Christophe, L.M.; ZHANG, Zhongsheng; (249 pag.)WO2016/29146; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem