Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54624-57-6, name is 2-Bromobenzimidazole, This compound has unique chemical properties. The synthetic route is as follows., 54624-57-6
Step 1. l-allyl-2-bromo-lH-benzo[d]imidazole [0724] A mixture of 2-bromo-lH-benzo[d] imidazole (0.400 g, 2.04 mmol), allyl bromide (0.35 mL, 4.08 mmol), 1,4-dioxane (15 mL), and 2 M aqueous sodium hydroxide solution (15 mL, 3.00 mmol) stirred for 2 h at 100 ¡ãC. The reaction mixture was cooled to room temperature and diluted with ethyl acetate (50 mL). The organic phase was separated and washed with brine (30 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. The residue was purified via preparative thin layer chromatography (eluting with 20percent ethyl acetate/petroleum ether) to afford 1- allyl-2-bromo-lH-benzo[d]imidazole (0.251 g, 52percent) as a yellow oil. MS (ESI, pos. ion) m/z 237, 239 [M+H]+.
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Reference:
Patent; BAIR, Kenneth W.; HERBERTZ, Torsten; KAUFFMAN, Goss Stryker; KAYSER-BRICKER, Katherine J.; LUKE, George P.; MARTIN, Matthew W.; MILLAN, David S.; SCHILLER, Shawn E. R.; TALBOT, Adam C.; WO2015/74064; (2015); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem