17228-38-5, These common heterocyclic compound, 17228-38-5, name is N-Methyl-1H-benzo[d]imidazol-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 5- (6-formyl-pyridin-2-yl)-thiophene-2-carboxylic acid [88mg, 0. [38MMOL,] Reference Example 14 (e)], [(LH-BENZOIMIDAZOL-2-YL)-METHYLAMINE] (60mg, 0.38mmol) and anhydrous ethanol (4ml) was stirred at room temperature for 2 hours, before sodium borohydride (30mg, 0.76mmol) was added. After stirring overnight the reaction mixture was concentrated, to provide 5-(6-{[(1H-benzoimidazol-2-ylmethyl)-amino]-methyl}- [PYRIDIN-2-YL)-THIOPHENE-2-CARBOXYLIC] acid as an off-white solid, which was used directly without further purification. LCMS (Method C): [RT] = 1.89 minutes; 365 (M+H) +.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17228-38-5.
Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2004/13130; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem