A common heterocyclic compound, 10394-38-4, name is 1-Methylbenzoimidazol-5-amine, molecular formula is C8H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 10394-38-4.
1-methyl-1H-benzo[d]imidazol-5-amine (100 mg, 0.67944 mmol),6-(4-((2,5-Dichloropyrimidin-4-yl)amino)piperidin-1-yl)nicotinonitrile (182 mg, 0.5212 mmol),Cs2CO3 (508.7 mg, 1.561 mmol),BINAP (34.6mg, 0.0556mmol) andPd(OAc) 2 (12.8 mg, 0.0570 mmol)The mixture was dissolved in 1,4-dioxane (10 mL). The reaction mixture is at 100 C,Stir for 4 hours in a nitrogen atmosphere.After the reaction was completed, it was concentrated under reduced pressure.The residue obtained was purified by silica gel column chromatography (DCM / MeOH (v/v) = 50/1)The title compound was obtained as a white solid (54.4mg, yield: 22.7%).
The synthetic route of 1-Methylbenzoimidazol-5-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Peng Ju; Li Xiaobo; Zhang Tao; Hu Haiyang; Chen Wuhong; Bai Changlin; Ke Donghua; Chen Peng; (217 pag.)CN109776522; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem