2034-22-2, A common compound: 2034-22-2, name is 2,4,5-Tribromoimidazole, belongs to imidazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
422.5 g of 2,4,5-tribromoimidazole, 1126.7 g of methanol were added to the reactor, 21.1 g of tetramethylammonium chloride was added, and 384.5 g of triphenylphosphine was added in portions while stirring.After the addition is complete, the reaction is incubated at 60-65C for about 1 hour until it reaches room temperature.Add ethyl acetate,While stirring, sodium bicarbonate solution was added dropwise, the layers were separated, and the organic layer was desolvated to precipitate a large amount of solids, which was then filtered and dried at room temperature to obtain 234.8 g of 4,5-dibromoimidazole in a yield of 75%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4,5-Tribromoimidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Dalian Qikai Pharmaceutical Technology Co., Ltd.; Jiang Bin; Jiang Dianping; Zhang Hongxue; (5 pag.)CN107827823; (2018); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem