104619-51-4, name is Di(1H-imidazol-1-yl)methanimine, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 104619-51-4
To a solution of 2-((dimethylamino)methyl)-6-nitrophenol (KR-400103) (5.74 mmol, 1.13 g) in methanol (120 mL), PtO2 (0.29 mmol, 0.07 g) was added. The reaction was flushed with argon followed by hydrogen for fifteen minutes each with constant magnetic stirring. The reaction was then stirred under hydrogen atmosphere at ordinary pressure (balloon) for ten hours. Argon wasagain flushed through the reaction vessel for 15 minutes. Then the reaction contents were filtered quickly over a thin pad of celite which was then immediately washed with methanol (50 mL). The filtrate was concentrated in vacuo yielding a brown solid. The solid was quickly re-dissolved in acetonitrile (120 mL) and di(imidazole-1-yl)methanimine (14.35 mmol, 2.31 g) was added with constant magnetic stirring. The reaction was then placed under argon atmosphere and refluxed for six hours. The reaction was concentrated under reduced pressure and silica gel column chromatography (10:1 chloroform/methanol) provided a colorless oil in an 81% yield. The product of the reduction (2-amino-6-((dimethylamino)methyl)phenol) is air unstable and appropriate measures should be taken to minimize air exposure. An analytical sample of the title compound was isolated by reverse-phase HPLC utilizing a gradient from 0.5-7% acetonitrile in water.
Statistics shows that 104619-51-4 is playing an increasingly important role. we look forward to future research findings about Di(1H-imidazol-1-yl)methanimine.
Reference:
Article; Rynearson, Kevin D.; Charrette, Brian; Gabriel, Christopher; Moreno, Jesus; Boerneke, Mark A.; Dibrov, Sergey M.; Hermann, Thomas; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3521 – 3525;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem