1402838-08-7, A common compound: 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, belongs to imidazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
The compound (2-oxo-2-(6-trifluoromethylbenzofuran-5-yl)ethyl) dimethyl phosphate (0207-30) (262 mg, 0.78 mmol, 1.2 eq.)2-(1-trityl-1H-imidazol-4-yl)benzaldehyde (0105-1) (270 mg, 0.65 mmol, 1.0 equiv) andCesium carbonate (847 mg, 2.6 mmol, 4.0 eq.)Mixed in isopropyl alcohol (20 ml),The mixture was stirred at room temperature for 16 hours.After the reaction was completed, quenched with water and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give a residue which was purified by column chromatography (petroleum ether/ethyl acetate=5/1 to 1/1). The target product (176 mg, yield: 43.3%) was obtained as a yellow gum.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(1-Trityl-4-imidazolyl)benzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Imidazole – Wikipedia,
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