934-22-5, A common heterocyclic compound, 934-22-5, name is 6-Aminobenzimidazole, molecular formula is C7H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 1; The preparation of 3-(1H-benzimidazol-5-ylamino)-4-(3-hydroxybenzylamino)cyclobut-3-ene-1,2-dione (?A1?) is carried out analogously to the following scheme 1.1 6.2 g (35.7 mmol) of 3,4-diethoxy-3-cyclobutene-1,2-dione 1 are dissolved in 50 ml of ethanol, 5.0 g (35.7 mmol) of 3H-benzimidazol-5-ylamine 2 are added, and the mixture is stirred at 75 C. for 20 h. The mixture is then subjected to conventional work-up, giving 8.93 g (97%) of 3-(1H-benzimidazol-5-ylamino)-4-ethoxycyclobut-3-ene-1,2-dione 3; MS-FAB (M+H+)=358, m.p. 243-244.
The synthetic route of 934-22-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mederski, Werner; Emde, Ulrich; Barnickel, Gerhard; Zenke, Frank; Greiner, Hartmut; Stieber, Frank; US2008/234266; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem