152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, 152628-02-9, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
10 g (0.0329 mol) of 2-propyl-4-methyl-6-(r-methylbenzimidazole-2- yl)benzimidazole (1) was dissolved in 60 ml of dimethylsulfoxide (DMSO). 3.7 g (0.0329 mol) of Potassium tert-butoxide was added to the aforementioned solution and stirred at room temperature (25-3O0C) for 30 min. Afterwards, 11.45 g (0.0329 mol) of tert-Butyl-4-bromomethylbiphenyl-2-carboxylate (2) was added and the obtained mixture was stirred at room temperature (25-3O0C) for 3 h. At this stage, the reaction was quenched with water (400 ml) and stirred for 30 min. The reaction mass was filtered. The resulting wet cake was slurried in water (200 ml) and stirred for 30 min. The reaction mass was filtered and the obtained solid was dried under vacuum at 60-650C until constant weight. 18.3 g obtained (93% HPLC).
Statistics shows that 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 152628-02-9.
Reference:
Patent; INKE, S.A.; SINGH, Santosh; JOSHI, Anil; NEWADKAR, Ravindranath; WO2010/149565; (2010); A1;,
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