1849-01-0, name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1849-01-0
Preparation of l-(3-iodopropyl)-3-methyl-l -benzor< |imidazol-2(3H)-one; [0176] A mixture of l-methyl-lH-benzo[i ]imidazol-2(3H)-one (2 g, 13.5 mmol, 1 equiv), 1- bromo-3-chloropropane (3.98 ml, 40.5 mmol, 3 equiv), and potassium carbonate (2.79 g, 20.25 mmol, 1.5 equiv) in NN-dimethylformamide was heated at 65C for 16 h. The reaction was cooled to ambient temperature and diluted with ethyl acetate. After being washed with water and brine, the organic layer was dried over MgS04, filtered, and concentrated in vacuo. The resulting residue was purified using the Biotage chromatography system (SNAP lOOg cartridge, Rf = 0.6, gradient - 10%- 50%) ethyl acetate/hexanes) to afford l-(3-chloropropyl)-3-methyl-lH-benzo[i ]imidazol-2(3H)-one as a clear oil (2.57 g, 85%); 'ffNMR (400 MHz, DMSO-i/6): delta 2.05-2.12 (m, 1H); 2.14-2.21 (m, 1H); 3.32 (s, 3H); 3.53 (t, 1H, J= 6.8 and 6.4 Hz); 3.66 (t, 1H, J= 6.4 Hz); 3.92-3.97 (m, 2H); 7.05- 7.09 (m, 2H); 7.12-7.16 (m, 1H); 7.17-7.21 (m, 1H); MS for CiiH13ClN20 m/z 226.07 (M+H)+.
Statistics shows that 1849-01-0 is playing an increasingly important role. we look forward to future research findings about 1-Methyl-1H-benzo[d]imidazol-2(3H)-one.
Reference:
Patent; ALTOS THERAPEUTICS, LLC; LUEHR, Gary, W.; SUNDARAM, Arathi; JAISHANKAR, Priyadarshini; PAYNE, Philip, W.; DRUZGALA, Pascal; WO2011/160084; (2011); A1;,
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