Adding some certain compound to certain chemical reactions, such as: 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1792-40-1. 1792-40-1
To a solution of 2-methyl-5-nitro-1H-benzimidazole (2) (9.0 g,0.05 mol) in ethanol (50 mL), K2CO3 (6.98 g, 0.075 mol) and benzylchloride (9.63 g, 0.075 mol) were refluxed for 8 h. After the completionof the reaction (monitored by TLC), the reaction mixturewas filtered and concentrated to give yellow solid. The residualmass was crystallized from ethanol to give mixture of 1-benzyl-2-methyl-5-nitro-1H-benzimidazole and 3-benzyl-2-methyl-5-nitro-3H-benzimidazole (3) in 75% yield. To a suspension of SnCl2 2H2O (15.45 g, 0.067 mol) in 2 N HCl (47.6 mL), 1/3-benzyl-2-methyl-5-nitro-1H/3H-benzimidazole (3) (4.25 g, 0.019 mol)was heated at 110 C for 7 h. After completion of the reaction,the suspension was neutralized with 2 N NaOH and diluted withethanol. Filtered the solid product and extracted the filtrate with chloroform, dried over Na2SO4, filtered and concentrated to getmixture of products which were separated through column chromatographyusing ethyl acetate/methanol (19:1) as eluent to getsolid compounds 4a and 4b.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-Methyl-5-nitro-1H-benzo[d]imidazole.
Reference:
Article; Singla, Prinka; Luxami, Vijay; Paul, Kamaldeep; Bioorganic and Medicinal Chemistry; vol. 23; 8; (2015); p. 1691 – 1700;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem