1792-40-1, A common compound: 1792-40-1, name is 2-Methyl-5-nitro-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
General procedure: 1/3-Butyl-2-methyl-5-nitro-1H/3H-benzimidazole was synthesized by previous reported method by the alkylation of 2-methyl-5-nitro-benzimidazole (0.05 mol) with butyl bromide (0.075 mol) in the presence of NaH (0.126 mol) in THF at room temperature for 8h. To a suspension of SnCl2.2H2O (135 mmol) in 2 N HCl (95.2 ml), 1/3-butyl-2-methyl-5-nitro-1H/3H-benzimidazole (36.4 mmol) was heated at 110 C for 7 h. After the completion of the reaction (monitored by TLC), the suspension was neutralized with 2 N NaOH and diluted with ethanol. Filtered the solid product and extracted the filtrate with chloroform, dried over Na2SO4, filtered and concentrated to get mixture of products which were separated through column chromatography using ethylacetate:methanol (9.5:0.5) to get pure solid compounds 2b and 2d.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methyl-5-nitro-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Sharma, Alka; Luxami, Vijay; Paul, Kamaldeep; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 414 – 422;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem