A common heterocyclic compound, 583-39-1, name is 2-Mercaptobenzimidazole, molecular formula is C7H6N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 583-39-1.
Acetic anhydride (30 mL, 0.033 mol) was added to 1H-benzo[d]imidazole-2(3H)-thione 1 (5 g,0.033 mol) and the stirred mixture was heated to 110-115 C for 30 min. The solution was cooledthen water (150 mL) was added, and finally kept for 30 min at room temperature. Colorless crystalswere filtered off (6.21 g, 97% Yield); TLC, Rf = 0.773 (1:1, n-hexane:ethyl acetate). The product wasrecrystallized from benzene to give white crystals. m.p. 201-202 C, (lit. [21] m.p., 195 C); IR (KBr) nu 1716 (C=O), 1368 (CH3), 2996 (CH aliphatic), and 3146 (CH aromatic), 1591 cm-1 (C=C). 1H-NMR(CDCl3/D2O) delta: 1.92 (s, 3H, CH3), 7.19 (m, 2H, Ar-H), and 7.26 ppm (m, 2H, Ar-H). 13C-NMR(DMSO-d6) delta: 27.1 (CH3), 108.5 (CH), 114.3 (CH), 122.3 (CH), 124.3 (CH), 129.8 (C), 130.1 (C), 168.9(C=S), and 171.1 ppm (C=O).
The synthetic route of 2-Mercaptobenzimidazole has been constantly updated, and we look forward to future research findings.
Reference:
Article; El Ashry, El Sayed H.; Kilany, Yeldez El; Nahas, Nariman M.; Barakat, Assem; Al-Qurashi, Nadia; Ghabbour, Hazem A.; Fun, Hoong-Kun; Molecules; vol. 21; 1; (2016);,
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