46006-36-4, name is 1H-Benzimidazole-7-carboxylic acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 46006-36-4
. [148] Into a 50-mL round-bottom flask, was placed lH-l,3-benzodiazole-4-carboxylic acid (42 mg, 0.26 mmol, 1.00 equiv), HATU (164 mg, 0.43 mmol, 1.50 equiv), DIEA (111 mg, 0.86 mmol, 3.00 equiv), 4,5,6,7-tetrahydro-2H-indazol-3-amine dihydrochloride (60.6 mg, 0.29 mmol, 1.10 equiv), N,N- dimethylformamide (5 mL). The resulting solution was stirred overnight at 25 C. The reaction mixture was diluted with DCM (50 mL), washed with H2O (50 mL x 3) and brine (50 mL x 3) and dried with Na2SC>4. After filtration, the filtrate was concentrated under vacuum. The crude product was purified by Prep-HPLC with the following conditions (Analyse HPLC-SHIMADZU): Column: XBridge Shield RP18 OBD Column, 5um, 19* 150mm; Mobile Phase A: water (0.1%FA), Mobile Phase B: ACN; Flow rate: 20 mL/min; Gradient: 3% B to 20% B in 17 min; 254 nm. The collected fraction was lyophilized to give 18.5 mg (25%) of (3-amino-4,5,6,7-tetrahydroindazol-2-yl)(lH-benzo[d]imidazol-4-yl)methanone (Example 48) as an off-white solid. Rt= 15.5 min; MS (ES, m/z) [M+H]+: 282; 1HNMR (DMSO- 6, 400MHz, ppm): delta 11.57(s, 1H); 8.71(s, 1H); 8.02(d, J=7.6, 1H); 7.87(d, J=8.0, 1H); 7.47-7.43(m, 1H); 2.61-2.58(m, 2H); 2.45-2.46(m, 2H); 1.76-1.67(m, 4H).
Statistics shows that 46006-36-4 is playing an increasingly important role. we look forward to future research findings about 1H-Benzimidazole-7-carboxylic acid.
Reference:
Patent; THE ROCKEFELLER UNIVERSITY; PONDA, Manish, P.; BRESLOW, Jan, L.; SELNICK, Harold; EGBERTSON, Melissa; (207 pag.)WO2017/205296; (2017); A1;,
Imidazole – Wikipedia,
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