1467-16-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1467-16-9 name is 1H-Imidazole hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 6 17-(5-cyanopyridin-3-yl)oestra-1,3,5(10),16-tetraene-3-carboxamide 17 mg (0.044 mmol) of 17-(5-cyanopyridin-3-yl)oestra-1,3,5(10),16-tetraene-3-carboxylic acid were initially charged in 0.4 ml of 2-methyltetrahydrofuran. Then 11 mg of 1,1′-carbonyldiimidazole and 2 mg of 1H-imidazole hydrochloride were added thereto and the mixture was stirred at room temp. for 18 h. Then 79 mul of 33% ammonia solution were added and the mixture was stirred at room temp. for 72 h, admixed with 10 ml of 1M hydrochloric acid solution, extracted with ethyl acetate and concentrated, and the crude product was purified by preparative HPLC (acetonitrile/water/formic acid). Yield: 9 mg of the title compound. 1H NMR (400 MHz, DMSO-d6): delta [ppm]=1.00 (s, 3H), 1.35-1.50 (m, 1H), 1.50-1.68 (m, 3H), 1.73 (td, 1H), 1.85-1.98 (m, 1H), 2.07-2.23 (m, 2H), 2.25-2.36 (m, 2H), 2.36-2.44 (m, partly concealed by DMSO signal), 2.83-2.95 (m, 2H), 6.33-6.36 (m, 1H), 7.19 (br. s., 1H), 7.31 (d, 1H), 7.55-7.61 (m, 2H), 7.82 (br. s., 1H), 8.28 (t, 1H), 8.87 (dd, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Imidazole hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BOTHE, Ulrich; BUSEMANN, Matthias; BARAK, Naomi; ROTGERI, Andrea; FISCHER, Oliver Martin; MARQUARDT, Tobias; (41 pag.)US2016/24142; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem