2849-93-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below.
The bispyridine ester amine compound (168 , 0.83 mmol) in Example 1 and benzoimidazole-2-carboxylic acid (190 , 1.17 mmol) were dissolved in DMF (5 ), HBTU (402 , 1.25 mmol) and triethylamine (0.58 , 4.17 mmol) were added to the solution, and the mixture was stirred at room temperature for 24 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a white solid (247 , 86 %) by chromatography (methanol : dichloromethane = 1:30).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY; WO2009/125923; (2009); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem