The chemical industry reduces the impact on the environment during synthesis 872-49-1, name is 5-Chloro-1-methylimidazole, I believe this compound will play a more active role in future production and life. 872-49-1
General procedure: 2-Chloropyrazine(0.64 g, 5.56 mmol), tetrakis(triphenylphosphine) palladium(0)(96 mg, 0.083 mmol), and potassium carbonate (0.77 g,5.56 mmol) were added to a solution of 22 (1.16 g, 2.78 mmol)in a mixed solvent of DMF-EtOH (2 : 1, 18 mL), and the mixturewas stirred at 90C for 2 h. The reaction solution was partitionedbetween water and EtOAc, and the organic layer waswashed with water and brine, dried over anhydrous MgSO4,filtered, and concentrated in vacuo. The residue was purifiedusing silica gel column chromatography (33-67% EtOAc inhexane) to yield 23a (0.79 g, 77%) as a colorless amorphous.
The chemical industry reduces the impact on the environment during synthesis 872-49-1. I believe this compound will play a more active role in future production and life.
Reference:
Article; Yamamoto, Shuji; Shibata, Tsuyoshi; Abe, Kumi; Oda, Koji; Aoki, Takeshi; Kawakita, Yasunori; Kawamoto, Hiroshi; Chemical and Pharmaceutical Bulletin; vol. 64; 9; (2016); p. 1321 – 1337;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem