The chemical industry reduces the impact on the environment during synthesis 1003-21-0, name is 5-Bromo-1-methyl-1H-imidazole, I believe this compound will play a more active role in future production and life. 1003-21-0
Pd(PPh3)4 (55.9 mg, 48.4 mumol) was added to a mixture of 6 (300 mg, 0.484 mmol) and 5-bromo-1-methylimidazole (312 mg, 1.94 mmol) in aqueous Na2CO3 (2 M, 1.0 mL, 2.0 mmol) and anhydrous THF (9.0 mL), and the solution was stirred at room temperature for 15 min. The resulting two-phase system was refluxed under stirring overnight, and was then allowed to cool to room temperature. To this was added water (25 mL), and the mixture was extracted with CHCl3 (50 mL¡Á3). The organic layer was washed with water (25 mL), dried over anhydrous MgSO4, and filtered. After the solvent was removed by evaporation, the residue was subjected to SEC fractionation to obtain 1 (150 mg, 59%) as a bluish white solid. Mp: 188.7-189.1 C. IR (KBr, cm-1): 1339, 1276, 1185, 1110, 1055, 989. 1H NMR (500 MHz, CDCl3): delta 7.51 (s, br, 2H, ArH), 7.15 (d, J=1.1Hz, 2H, ArH), 7.00 (s, 2H, ArH), 3.68 (s, 6H, NCH3), 2.02 (s, 6H, CH3). 13C NMR (125 MHz, CDCl3): delta 142.1, 139.8, 129.7, 129.3, 125.7, 125.6, 125.4, 32.7, 14.4. MS (ESI+): m/z=529 [M+H]+. Anal. Calcd for C23H18F6N4S2: C, 52.27; H, 3.43; N, 10.60. Found: C, 52.03; H, 3.46; N, 10.54.
The chemical industry reduces the impact on the environment during synthesis 1003-21-0. I believe this compound will play a more active role in future production and life.
Reference:
Article; Iida, Hiroki; Umebayashi, Naofumi; Yashima, Eiji; Tetrahedron; vol. 69; 52; (2013); p. 11064 – 11069;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem