Discovery of 2-(1H-Imidazol-5-yl)ethanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1H-Imidazol-5-yl)ethanol, and friends who are interested can also refer to it.

872-82-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 872-82-2 name is 2-(1H-Imidazol-5-yl)ethanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-lmidazoleacetic acid hydrochloride (5.93 g, 36.47 mmol) in methanol (125 mL) was saturated with HCI gas and stirred at room temperature for 5.5 h, then concentrated to give a quantitative yield of 4-imidazoleacetic acid methyl ester hydrochloride as a white solid which had NMR (MeOH- d4) delta 8.87 (d, J = 1.2 Hz, 1H), 7.46 (s, 1 H), 3.89 (s, 2H) 3.72 Patent; PFIZER PRODUCTS INC.; WO2007/34277; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem