641571-11-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
1006361 A solution of 3 -((4-(5-methoxypyridin-3 -yl)pyrimidin-2-yl)amino)-4-methylbenzoic acid (6.4 g, 19.02 mmol) in NMP (64 mL) was dropwise charged with thionylchloride (2.7 g, 22.8 mmol) at room temperature and heated to 60 C for 1 h. The solution wascharged with 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (5.5 g, 22.8 mmol) andheated to 90 C for 3 h. The reaction mixture was diluted with water (120 mL), adjusted pH to10 with 40% aqueous sodium hydroxide solution and stirred at 80 C for 30 mm. The reactionmixture was cooled to 40 C and the solid precipitated out was filtered and washed with water.The residue obtained was again stirred in water at 40 C for 1 h and solid was filtered and driedto give 5.60 g, 52% yield of the title compound as a white solid. ?H NMR (400 MHz, DMSO-= 10.61 (s, 1 H), 9.16 (s, 1 H), 8.88 (d, J= 1.34 Hz, 1 H), 8.56 (d, J= 4.91 Hz, 1 H), 8.36- 8.42 (m, 2 H), 8.28 (s, 1 H), 8.15 -8.21 (m, 2 H), 7.95 -8.00 (m, 1 H), 7.69-7.79 (m, 2 H),7.52 (d, J= 5.35 Hz, 1 H), 7.41 -7.50 (m, 2 H), 3.83 (s, 3 H), 2.37 (s, 3 H), 2.18 (s, 3 H); MS(ES): m/z = 560.30 [M+H] LCMS: tR = 2.61 mm.
The synthetic route of 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem