67085-11-4, These common heterocyclic compound, 67085-11-4, name is 4-(4-Chlorophenyl)-1-(1H-imidazol-1-yl)butan-2-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Take 5kg of 1-(2-hydroxy-4-(4-chlorophenyl)butyl)-1H-imidazole and dissolve it sufficiently in 35kg of methylene chloride. 5kg of thionyl chloride was added dropwise at a rate of 1.5ml/s at 20C, and the temperature was slowly raised to 32C and the reaction was incubated for 1 hour. Then reflux at 60 C for 1 hour, slowly cooled to 15 C to obtain the reaction solution; In the reaction solution, 10 C. water was added at a rate of 0.5 ml/s with stirring, and the volume ratio of the reaction solution to water was 0.005:1. Anhydrous sodium carbonate was further added at 1.0 to 1.5 kg/L. After suction filtration, the solid was discarded, the liquid was concentrated at 55 C. until no dichloromethane was distilled off, and dried to obtain 1-(2-chloro-4-(4-chlorophenyl)butyl)-1-hydro-imidazole. The purity is 99.17%. The 1-(2-chloro-4-(4-chlorophenyl)butyl)-1H-imidazole was used as a raw material in Examples 1 to 5.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 67085-11-4.
Reference:
Patent; Zhuzhou Qianjin Pharmaceutical Co., Ltd.; Peng Kaifeng; Wen Fengqiu; Bai Lu; Li Sanxin; Gong Yun; Li Fujun; (12 pag.)CN105198816; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem