Analyzing the synthesis route of 5-Methoxy-1H-benzo[d]imidazole

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4887-80-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4887-80-3, name is 5-Methoxy-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: PhI(OAc)2 (0.5 mmol) was added to a mixture of 1H-benzimidazole(1a; 0.5 mmol), isochroman (2a; 2.0 mmol), and DCE (2.0mL) in a Schlenk tube at r.t. The mixture was stirred at 80 C for6 h then cooled. H2O (10 mL) was added, and the mixture wasextracted with CH2Cl2 (3 ¡Á 10 mL). The combined organic layerwas dried (Na2SO4) and concentrated under reduced pressure.The residues were purified by flash column chromatography(silica gel, hexane-EtOAc) to give a colorless oil; yield: 115 mg(92%).

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Reference:
Article; Sun, Bin; Yan, Zhiyang; Jin, Can; Su, Weike; Synlett; vol. 29; 18; (2018); p. 2432 – 2436;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem