22884-10-2, Adding a certain compound to certain chemical reactions, such as: 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22884-10-2.
To a 50 mL flask was added 4-trifluoromethyl-2-azidoaniline1c (1 mmol), alpha-bromotrifluoroacetone (1.2mmol) And potassium carbonate (1.5mmol), React at 45 C, The reaction solvent was chloroform (20 mL). After 2 hours of reaction, Additional diphenylmethylphosphine (1.5 mmol) was added. The reaction was carried out at 30 C, and after continuing the reaction for 3 hours, The solvent chloroform was removed under reduced pressure. The intermediate was transferred to a solution of triphenylphosphine (2.5 mmol) and elemental iodine (2.5 mmol) in chloroform (15 mL). Then add imidazoleacetic acid (1.5 mmol), React at 45 C, Reaction for 2 hours, After the reaction is completed, The solvent chloroform was removed under reduced pressure. The primary product was subjected to column chromatography to give 0.192 g of the title compound 2c, yield 51%.
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Reference:
Patent; Hubei Wenli College; He Ping; Wang Liping; Pei Fei; Jin Shan; Ren Zhilin; Wang Long; (10 pag.)CN109400589; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem