35203-44-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35203-44-2 as follows.
Take a 100 mL two-necked flask, add N-propyl imidazole (2.64 g, 18.0 mmol), 35 mL toluene,3-Bromopropylphenylethoxyphosphine oxide (6.26 g, 20.0 mmol) was added dropwise with heating and stirring;The reaction was performed at 85¡ãC for 6 h and cooled to room temperature. Pour out the upper toluene,Add 100mL of deionized water to dissolve the product to obtain an aqueous phase.The aqueous phase was washed with an EtOAc_PE=3:1 organic phase (30 mL x 4) to separate the aqueous phase two;Di(2-ethylhexyl)phosphate (P204) (5.60 g, 18.0 mmol) was refluxed under the action of sodium for 24 h.The resulting sodium salt was dissolved in dichloromethane and the previously separated aqueous phase was stirred at room temperature for 3 h.Add 50 mL of CH2Cl2 and stir to separate the organic phase. Wash the organic phase with deionized water (20 mL x 5)Separate the organic phase two, add anhydrous Na2SO4 to dry the organic phase two, filter,The majority of CH2Cl2 was evaporated under reduced pressure and dried under vacuum at 70¡ã C. for 3 h to give 12.50 g of pale yellow viscous liquid (94percent yield).
According to the analysis of related databases, 1-Propyl-1H-imidazole, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ningbo University; Wang Junping; Liang Hongze; Feng Da; Zhao Jieying; Kang Xinchun; Zhang Xiaozhen; Shen Fei; Huang Feilong; (21 pag.)CN104945435; (2018); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem